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Moduretic 5\50mg 30 Tablets

EGP45

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Medication Name: Moduretic 5/50mg 30 Tablets

Active Ingredients (per tablet):

  • Amiloride Hydrochloride 5 mg

  • Hydrochlorothiazide 50 mg

Pharmacological Class:
Combination diuretic (Potassium-sparing + Thiazide diuretic)

Dosage Form:
Tablets — 30 per pack

Indications:

  • Treatment of hypertension (high blood pressure).

  • Management of edema (fluid retention) associated with congestive heart failure, liver cirrhosis, or certain kidney disorders.

  • Used when there is a risk of low potassium levels (hypokalemia) due to thiazide therapy.

Mechanism of Action:

  • Hydrochlorothiazide increases the excretion of sodium and water by acting on the distal tubules of the kidney.

  • Amiloride helps retain potassium by blocking sodium reabsorption in the distal tubules, preventing potassium loss.
    The combination provides effective diuresis while minimizing potassium depletion.

Dosage:

  • Usual adult dose: 1 tablet daily, preferably in the morning to avoid nighttime urination.

  • Dosage may be adjusted according to patient response and clinical condition.

Precautions:

  • Avoid potassium supplements or potassium-rich diets unless prescribed.

  • Use cautiously in patients with kidney or liver impairment.

  • Monitor electrolytes, especially potassium and sodium levels, during therapy.

  • Contraindicated in severe renal impairment, hyperkalemia, or Addison’s disease.

Common Side Effects:

  • Dizziness or lightheadedness

  • Increased urination

  • Headache

  • Fatigue

  • Gastrointestinal upset

  • Elevated potassium levels (hyperkalemia) in susceptible patients

Note:
Moduretic offers the advantage of maintaining normal potassium balance while providing effective blood pressure and fluid control.

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