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Coveram 5\10mg 15 Tablets

EGP133

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Indications:

  • Essential hypertension (high blood pressure)

  • Stable coronary artery disease (angina prevention and control)

  • Used when treatment with both agents (ACE inhibitor + calcium channel blocker) is appropriate

Mechanism of Action:

  • Perindopril: Inhibits ACE enzyme, reducing angiotensin II and aldosterone production → causes vasodilation and decreases blood pressure.

  • Amlodipine: Blocks calcium influx into vascular smooth muscle → relaxes blood vessels and improves blood flow.

  • Combined effect lowers blood pressure and improves cardiac oxygen delivery.

Precautions:

  • Monitor blood pressure, renal function, and potassium levels regularly.

  • Use cautiously in patients with renal impairment, heart failure, or liver disease.

  • Avoid in pregnancy and breastfeeding.

  • Avoid combining with potassium-sparing diuretics or potassium supplements without medical supervision.

Common Side Effects:

  • Dizziness or fatigue

  • Headache

  • Swelling of ankles or feet (from amlodipine)

  • Dry cough (from perindopril)

  • Flushing or palpitations

  • Nausea or abdominal discomfort

  • Low blood pressure

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