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Myodura 10mg 30 Tablets

EGP93

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Indications:

  • Relief of muscle spasticity associated with conditions such as multiple sclerosis, spinal cord injury, or chronic back pain.

  • Treatment of acute painful muscle spasms due to musculoskeletal disorders (e.g., cervical or lumbar pain).

Mechanism of Action:
Tizanidine acts on α₂-adrenergic receptors in the spinal cord to inhibit presynaptic motor neuron activity, leading to reduced muscle tone and relief from spasticity and pain.

Dosage:

  • Typical adult dose: 2–4 mg up to three times daily, depending on severity.

  • Maximum recommended total daily dose: 36 mg.

  • For mild cases, 5 mg once or twice daily may suffice.

  • Dose should be individualized and titrated gradually.

Precautions:

  • Avoid abrupt discontinuation to prevent rebound hypertension and tachycardia.

  • Use cautiously in patients with liver impairment; monitor liver function regularly.

  • May cause drowsiness—avoid driving or operating machinery.

  • Avoid combining with strong CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine).

  • Alcohol and CNS depressants may increase sedation.

Common Side Effects:

  • Drowsiness or fatigue

  • Dizziness

  • Dry mouth

  • Hypotension (low blood pressure)

  • Muscle weakness

  • Gastrointestinal discomfort

Note:
Myodura 5mg provides effective relief from muscle spasm and stiffness while maintaining tolerability when used under careful dosage control.

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