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Epi-Dinitra 5mg 30 Sublingual Tablets

EGP16

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Epi-Dinitra 5 mg (30 Sublingual Tablets)

Active Ingredient:

  • Isosorbide Dinitrate 5 mg – Organic nitrate vasodilator

Therapeutic Class:
Antianginal and vasodilator medication

Indications:

  • Relief and prevention of angina pectoris (chest pain due to coronary artery disease)

  • Adjunct treatment in heart failure (to reduce cardiac workload)

Dosage and Administration:

  • Acute angina attack: Place one tablet under the tongue and allow it to dissolve completely.

  • If pain persists after 5–10 minutes, another tablet may be taken.

  • Maximum: 3 tablets within 15–30 minutes (seek medical attention if no relief).

  • Prophylaxis: One tablet 15–30 minutes before activities likely to provoke angina (e.g., exertion, stress).

  • Do not swallow the tablet; sublingual absorption provides rapid onset of action (1–3 minutes).

Mechanism of Action:

  • Converts to nitric oxide in vascular smooth muscle, causing vasodilation.

  • Reduces preload and afterload, lowering myocardial oxygen demand.

  • Improves coronary blood flow to ischemic heart tissue.

Precautions:

  • Contraindicated in:

    • Severe hypotension or shock

    • Use of phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil) within the last 24–48 hours

    • Severe anemia or increased intracranial pressure

  • Use with caution in:

    • Glaucoma, thyroid disease, or hepatic impairment

    • Patients with volume depletion or orthostatic hypotension

  • Tolerance may develop with continuous use—intermittent dosing schedules are recommended.

Possible Side Effects:

  • Headache (very common, due to vasodilation)

  • Flushing or dizziness

  • Hypotension (especially when standing)

  • Reflex tachycardia

  • Nausea or lightheadedness

Storage:

  • Store below 25°C in a tightly closed container, protected from light and moisture.

  • Keep out of reach of children.

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