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Exforge 10\160mg 14 Tablets

EGP218

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Exforge 10/160 mg (14 Tablets)

Active Ingredients:

  • Amlodipine 10 mg – Calcium channel blocker

  • Valsartan 160 mg – Angiotensin II receptor blocker (ARB)

Therapeutic Class:
Antihypertensive combination (Calcium channel blocker + ARB)

Indications:

  • Treatment of essential hypertension in patients not adequately controlled by monotherapy

  • May be used as a replacement therapy for patients already receiving the two components separately

Dosage:

  • Usual dose: One tablet once daily

  • May be taken with or without food

  • Dose should be individualized based on blood pressure response and tolerance

Mechanism of Action:

  • Amlodipine: Relaxes vascular smooth muscle by inhibiting calcium ion influx, resulting in vasodilation and reduced peripheral resistance.

  • Valsartan: Blocks angiotensin II at the AT1 receptor, preventing vasoconstriction and reducing aldosterone secretion, leading to lowered blood pressure.

Precautions:

  • Contraindicated in:

    • Pregnancy (especially 2nd and 3rd trimesters)

    • Severe hepatic or renal impairment

    • Known hypersensitivity to amlodipine, valsartan, or other dihydropyridine derivatives

  • Use with caution in:

    • Patients with heart failure or left ventricular dysfunction

    • Severe aortic stenosis

    • Dehydration or electrolyte imbalance (especially low sodium or high potassium)

Possible Side Effects:

  • Dizziness, headache, or fatigue

  • Peripheral edema (swelling of ankles or legs)

  • Flushing

  • Hypotension

  • Nausea or abdominal discomfort

  • Muscle cramps (rare)

Storage:

  • Store below 30°C in a dry place, protected from light and moisture

  • Keep out of reach of children

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