Indomethacin 100mg 10 Rectal Suppositories

Product Name: Indomethacin 100mg 10 Rectal Suppositories

Category: Nonsteroidal Anti-Inflammatory Drug (NSAID)

Composition

Each suppository contains:

• Indomethacin – 100 mg

Indications

• Relief of pain and inflammation associated with:

  • Rheumatoid arthritis

  • Osteoarthritis

  • Ankylosing spondylitis

  • Acute gout attacks

  • Musculoskeletal pain

• Short-term management of postoperative pain

Mechanism of Action

• Indomethacin inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis.

• This results in anti-inflammatory, analgesic, and antipyretic effects.

Dosage & Administration

• Route: Rectal

• Adults: Usually one 100 mg suppository once daily at bedtime.

• The dose may be adjusted by the physician according to clinical response.

• Do not exceed the recommended daily dose.

Contraindications

• Hypersensitivity to indomethacin or other NSAIDs

• History of gastrointestinal bleeding or ulcers

• Severe renal or hepatic impairment

• Pregnancy (especially in the third trimester)

Precautions

• Use with caution in elderly patients

• Monitor for gastrointestinal irritation or bleeding

• Avoid concurrent use with other NSAIDs or corticosteroids

• Use the lowest effective dose for the shortest duration possible

Side Effects

• Nausea, abdominal pain, or diarrhea

• Headache or dizziness

• Rectal irritation

• Rarely, gastrointestinal bleeding or ulceration

Storage

• Store below 25°C

• Protect from heat and moisture

• Keep out of reach of children