Dolabactin 400mg 5 Tablets

Medication Name: Dolabactin 400 mg Tablets (5 Tablets)

Active Ingredient: Moxifloxacin 400 mg

Pharmacologic Class: Fluoroquinolone antibiotic

Indications:

• Community-acquired pneumonia.
• Acute bacterial sinusitis.
• Acute exacerbation of chronic bronchitis.
• Uncomplicated and complicated skin and soft tissue infections.
• Complicated intra-abdominal infections.

Dosage and Administration:

• Adults: 400 mg once daily.
• The duration of treatment depends on the type and severity of the infection (e.g., typically 5 days for acute bacterial sinusitis, 7-14 days for complicated skin infections).
• May be taken with or without food.
• Swallow the tablet whole with a glass of water.
• It is crucial to complete the full course of treatment as prescribed, even if symptoms improve early.

Contraindications:

• Hypersensitivity to moxifloxacin, other fluoroquinolones (e.g., ciprofloxacin, levofloxacin), or any component of the formulation.
• Patients with a history of tendon disorders or rupture related to fluoroquinolone use.
• Congenital or documented acquired QT prolongation or patients taking drugs that prolong the QT interval (e.g., Amiodarone, Sotalol).²

   

• Uncorrected hypokalemia (low potassium levels).³

   

• Children and adolescents under 18 years of age (due to potential risk of joint/cartilage damage).
• Patients with uncompensated liver impairment.

Precautions:

• Tendon Rupture/Tendinitis: Discontinue immediately if pain, inflammation, or rupture of a tendon (especially the Achilles tendon) occurs. The risk is higher in the elderly, kidney/heart/lung transplant recipients, and those on corticosteroids.
• QT Prolongation: Use with extreme caution in patients with cardiac conditions (like bradycardia, ischemia) or those taking other drugs that affect heart rhythm.⁴

   

• Central Nervous System (CNS) Effects: May cause dizziness, seizures, or confusion. Use cautiously in patients with known CNS disorders or epilepsy.
• Peripheral Neuropathy: Stop the medication immediately if symptoms of peripheral neuropathy (pain, burning, tingling, numbness, or weakness) appear, as it may become irreversible.
• Photosensitivity: Avoid excessive sunlight and artificial UV light exposure during treatment and for several days after.
• Drug Interactions: Must be taken at least 4 hours before or 8 hours after products containing magnesium, aluminum, iron, or zinc (including antacids and multivitamins) as these can significantly reduce absorption.⁵

   

Common Side Effects:

• Nausea, vomiting, diarrhea, or abdominal pain.
• Headache or dizziness.
• Insomnia (difficulty sleeping).
• Change in taste sensation.
• Mild changes in liver enzyme levels.

Serious Side Effects (rare):

• Tendon rupture (tendinitis).
• Severe allergic reaction (Anaphylaxis, Angioedema).
• Serious skin reactions (e.g., Stevens-Johnson syndrome).
• Life-threatening heart rhythm changes (QT prolongation, Torsades de Pointes).⁶

   

• Severe liver damage or hepatitis.
• Clostridioides difficile-associated diarrhea (CDAD).

Storage Conditions:

• Store at room temperature, typically below $25^\circ \text{C}$ or $30^\circ \text{C}$.
• Protect from light, heat, and moisture.
• Keep out of reach of children.