{"id":3992,"date":"2025-10-24T08:08:40","date_gmt":"2025-10-24T08:08:40","guid":{"rendered":"https:\/\/nawarpharmacy.com\/?post_type=product&#038;p=3992"},"modified":"2025-10-25T14:06:53","modified_gmt":"2025-10-25T14:06:53","slug":"entresto-50mg-28-tablets","status":"publish","type":"product","link":"https:\/\/nawarpharmacy.com\/ru\/product\/entresto-50mg-28-tablets\/","title":{"rendered":"Entresto 50mg 28 Tablets"},"content":{"rendered":"<p data-start=\"0\" data-end=\"33\"><strong data-start=\"0\" data-end=\"31\">Entresto 50 mg (28 Tablets)<\/strong><\/p>\n<p data-start=\"35\" data-end=\"60\"><strong data-start=\"35\" data-end=\"58\">Active Ingredients:<\/strong><\/p>\n<ul data-start=\"61\" data-end=\"230\">\n<li data-start=\"61\" data-end=\"230\">\n<p data-start=\"63\" data-end=\"230\"><strong data-start=\"63\" data-end=\"101\">Sacubitril 24 mg \/ Valsartan 26 mg<\/strong> per tablet (Note: the exact composition may vary depending on formulation; \u201c50 mg\u201d usually refers to the sacubitril component)<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"232\" data-end=\"353\"><strong data-start=\"232\" data-end=\"254\">Therapeutic Class:<\/strong><br data-start=\"254\" data-end=\"257\" \/>Angiotensin receptor-neprilysin inhibitor (ARNI) \u2013 Antihypertensive \/ Heart failure management<\/p>\n<p data-start=\"355\" data-end=\"373\"><strong data-start=\"355\" data-end=\"371\">Indications:<\/strong><\/p>\n<ul data-start=\"374\" data-end=\"609\">\n<li data-start=\"374\" data-end=\"444\">\n<p data-start=\"376\" data-end=\"444\"><strong data-start=\"376\" data-end=\"432\">Heart failure with reduced ejection fraction (HFrEF)<\/strong> in adults<\/p>\n<\/li>\n<li data-start=\"445\" data-end=\"529\">\n<p data-start=\"447\" data-end=\"529\">Used to <strong data-start=\"455\" data-end=\"506\">reduce cardiovascular death and hospitalization<\/strong> due to heart failure<\/p>\n<\/li>\n<li data-start=\"530\" data-end=\"609\">\n<p data-start=\"532\" data-end=\"609\">Often prescribed in combination with other standard heart failure therapies<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"611\" data-end=\"624\"><strong data-start=\"611\" data-end=\"622\">Dosage:<\/strong><\/p>\n<ul data-start=\"625\" data-end=\"852\">\n<li data-start=\"625\" data-end=\"703\">\n<p data-start=\"627\" data-end=\"703\"><strong data-start=\"627\" data-end=\"648\">Usual adult dose:<\/strong> One tablet twice daily, as directed by the physician<\/p>\n<\/li>\n<li data-start=\"704\" data-end=\"750\">\n<p data-start=\"706\" data-end=\"750\">Take consistently <strong data-start=\"724\" data-end=\"748\">with or without food<\/strong><\/p>\n<\/li>\n<li data-start=\"751\" data-end=\"852\">\n<p data-start=\"753\" data-end=\"852\">Dose adjustments may be needed based on <strong data-start=\"793\" data-end=\"850\">kidney function, blood pressure, and potassium levels<\/strong><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"854\" data-end=\"880\"><strong data-start=\"854\" data-end=\"878\">Mechanism of Action:<\/strong><\/p>\n<ul data-start=\"881\" data-end=\"1249\">\n<li data-start=\"881\" data-end=\"1015\">\n<p data-start=\"883\" data-end=\"1015\"><strong data-start=\"883\" data-end=\"898\">Sacubitril:<\/strong> Neprilysin inhibitor \u2013 increases levels of natriuretic peptides, promoting vasodilation, natriuresis, and diuresis<\/p>\n<\/li>\n<li data-start=\"1016\" data-end=\"1145\">\n<p data-start=\"1018\" data-end=\"1145\"><strong data-start=\"1018\" data-end=\"1032\">Valsartan:<\/strong> Angiotensin II receptor blocker \u2013 reduces vasoconstriction and aldosterone-mediated sodium and water retention<\/p>\n<\/li>\n<li data-start=\"1146\" data-end=\"1249\">\n<p data-start=\"1148\" data-end=\"1249\">Combination provides <strong data-start=\"1169\" data-end=\"1192\">synergistic effects<\/strong> in lowering blood pressure and reducing cardiac strain<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1251\" data-end=\"1269\"><strong data-start=\"1251\" data-end=\"1267\">Precautions:<\/strong><\/p>\n<ul data-start=\"1270\" data-end=\"1655\">\n<li data-start=\"1270\" data-end=\"1455\">\n<p data-start=\"1272\" data-end=\"1293\">Contraindicated in:<\/p>\n<ul data-start=\"1296\" data-end=\"1455\">\n<li data-start=\"1296\" data-end=\"1327\">\n<p data-start=\"1298\" data-end=\"1327\">Pregnancy and breastfeeding<\/p>\n<\/li>\n<li data-start=\"1330\" data-end=\"1396\">\n<p data-start=\"1332\" data-end=\"1396\">History of angioedema related to ARBs or neprilysin inhibitors<\/p>\n<\/li>\n<li data-start=\"1399\" data-end=\"1455\">\n<p data-start=\"1401\" data-end=\"1455\">Severe hepatic impairment or end-stage renal disease<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"1456\" data-end=\"1575\">\n<p data-start=\"1458\" data-end=\"1480\">Use with caution in:<\/p>\n<ul data-start=\"1483\" data-end=\"1575\">\n<li data-start=\"1483\" data-end=\"1512\">\n<p data-start=\"1485\" data-end=\"1512\">Moderate renal impairment<\/p>\n<\/li>\n<li data-start=\"1515\" data-end=\"1557\">\n<p data-start=\"1517\" data-end=\"1557\">Hyperkalemia or electrolyte imbalances<\/p>\n<\/li>\n<li data-start=\"1560\" data-end=\"1575\">\n<p data-start=\"1562\" data-end=\"1575\">Hypotension<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"1576\" data-end=\"1655\">\n<p data-start=\"1578\" data-end=\"1655\"><strong data-start=\"1578\" data-end=\"1643\">Monitor blood pressure, kidney function, and potassium levels<\/strong> regularly<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1657\" data-end=\"1685\"><strong data-start=\"1657\" data-end=\"1683\">Possible Side Effects:<\/strong><\/p>\n<ul data-start=\"1686\" data-end=\"1821\">\n<li data-start=\"1686\" data-end=\"1714\">\n<p data-start=\"1688\" data-end=\"1714\">Hypotension or dizziness<\/p>\n<\/li>\n<li data-start=\"1715\" data-end=\"1748\">\n<p data-start=\"1717\" data-end=\"1748\">Hyperkalemia (high potassium)<\/p>\n<\/li>\n<li data-start=\"1749\" data-end=\"1758\">\n<p data-start=\"1751\" data-end=\"1758\">Cough<\/p>\n<\/li>\n<li data-start=\"1759\" data-end=\"1780\">\n<p data-start=\"1761\" data-end=\"1780\">Kidney impairment<\/p>\n<\/li>\n<li data-start=\"1781\" data-end=\"1821\">\n<p data-start=\"1783\" data-end=\"1821\">Rare: angioedema, severe hypotension<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1823\" data-end=\"1837\"><strong data-start=\"1823\" data-end=\"1835\">Storage:<\/strong><\/p>\n<ul data-start=\"1838\" data-end=\"1940\" data-is-last-node=\"\" data-is-only-node=\"\">\n<li data-start=\"1838\" data-end=\"1908\">\n<p data-start=\"1840\" data-end=\"1908\">Store below 25\u00b0C in a dry place, protected from light and moisture<\/p>\n<\/li>\n<li data-start=\"1909\" data-end=\"1940\" data-is-last-node=\"\">\n<p data-start=\"1911\" data-end=\"1940\" data-is-last-node=\"\">Keep out of reach of children<\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Entresto 50 mg (28 Tablets) Active Ingredients: Sacubitril 24 mg \/ Valsartan 26 mg per tablet (Note: the exact composition may vary depending on formulation; \u201c50 mg\u201d usually refers to the sacubitril component) Therapeutic Class:Angiotensin receptor-neprilysin inhibitor (ARNI) \u2013 Antihypertensive \/ Heart failure management Indications: Heart failure with reduced ejection fraction (HFrEF) in adults Used&#8230;<\/p>\n","protected":false},"featured_media":4253,"comment_status":"open","ping_status":"closed","template":"","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","_bst_post_transparent":"default","_bst_post_title":"","_bst_post_layout":"default","_bst_post_sidebar_id":"","_bst_post_content_style":"default","_bst_post_vertical_padding":"default","_bst_post_feature":"","_bst_post_feature_position":"","_bst_post_header":false,"_bst_post_footer":false},"product_brand":[],"product_cat":[80,45],"product_tag":[],"product_brands":[],"class_list":{"0":"post-3992","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cardiovascular-blood-pressure","7":"product_cat-medicines","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-simple","14":"entry","15":"content-bg","16":"loop-entry"},"_links":{"self":[{"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/product\/3992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/comments?post=3992"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/media\/4253"}],"wp:attachment":[{"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/media?parent=3992"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/product_brand?post=3992"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/product_cat?post=3992"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/product_tag?post=3992"},{"taxonomy":"product_brands","embeddable":true,"href":"https:\/\/nawarpharmacy.com\/ru\/wp-json\/wp\/v2\/product_brands?post=3992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}