Angiofox 50mg 20 Capsules

Angiofox 50 mg (20 Capsules)

Active Ingredient:

• Captopril 50 mg – Angiotensin-Converting Enzyme (ACE) Inhibitor

Therapeutic Class:
Antihypertensive and cardioprotective agent (ACE inhibitor)

Indications:

• Hypertension (high blood pressure)

• Heart failure (as part of combination therapy)

• Post-myocardial infarction (to improve survival and prevent heart remodeling)

• Diabetic nephropathy (kidney protection in diabetic patients)

Dosage:

• Usual adult dose:

  • Hypertension: 25–50 mg 2–3 times daily

  • Heart failure: Initially 6.25–12.5 mg 2–3 times daily, titrated as tolerated

• Should be taken 1 hour before meals (food decreases absorption)

• Dose adjustment is required in patients with renal impairment

Mechanism of Action:

• Inhibits conversion of angiotensin I to angiotensin II

• Reduces vasoconstriction and aldosterone secretion

• Leads to vasodilation, decreased blood pressure, and reduced cardiac workload

Precautions:

• Contraindicated in:

  • History of angioedema with ACE inhibitors

  • Pregnancy (especially 2nd and 3rd trimesters)

  • Severe renal impairment or bilateral renal artery stenosis

• Use cautiously in:

  • Patients with kidney disease or volume depletion

  • Diabetics using insulin or oral hypoglycemics (risk of hypoglycemia)

  • Patients on potassium supplements or potassium-sparing diuretics (risk of hyperkalemia)

• Regular monitoring of renal function, potassium, and blood pressure is advised

Possible Side Effects:

• Dry, persistent cough (common with ACE inhibitors)

• Dizziness or hypotension, especially after the first dose

• Increased potassium levels (hyperkalemia)

• Fatigue or weakness

• Rare: Angioedema, rash, or loss of taste (dysgeusia)

Storage:

• Store below 25°C in a dry place, protected from moisture and sunlight

• Keep out of reach of children