Silden 100mg 8 Tablets

Medication Name: Sildenafil

Pharmacological Class:
Phosphodiesterase type 5 (PDE5) inhibitor

Active Ingredient:
Sildenafil citrate

Indications:

• Erectile dysfunction (ED): Enhances the ability to achieve and maintain an erection during sexual stimulation.

• Pulmonary arterial hypertension (PAH): Reduces pulmonary pressure and improves exercise tolerance.

Mechanism of Action:
Sildenafil blocks the PDE5 enzyme responsible for the breakdown of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels relax smooth muscle in penile blood vessels, increasing blood flow to the corpus cavernosum and facilitating erection.

Dosage and Administration:

• Erectile Dysfunction: 50 mg taken approximately 1 hour before sexual activity; dose may be adjusted between 25–100 mg once daily as needed.

• Pulmonary Arterial Hypertension: 20 mg taken three times daily (about 4–6 hours apart).

• Take with water; avoid high-fat meals that can delay absorption.

Contraindications:

• Concomitant use with nitrates or nitric oxide donors.

• Severe cardiovascular conditions or unstable angina.

• Severe hepatic impairment or hereditary retinal disorders.

Precautions:

• Use cautiously in patients with low blood pressure, renal impairment, or recent stroke or myocardial infarction.

• Avoid alcohol consumption due to risk of additive hypotension.

• Not recommended for women or children.

Common Adverse Effects:

• Headache

• Flushing

• Dizziness

• Nasal congestion

• Dyspepsia

• Visual disturbances (blurred or blue-tinted vision)

Serious Adverse Effects (rare):

• Priapism (erection lasting longer than 4 hours)

• Sudden loss of vision or hearing

• Severe hypotension

Onset of Action:
30–60 minutes after oral administration

Duration of Effect:
Approximately 4–5 hours

Storage:
Store below 30°C, in a dry place away from light and moisture.