Megamox ES 642 mg Suspension 100 ML

Medication Name: Megamox ES 642mg Suspension 100ml

Active Ingredients (per 5 ml):

• Amoxicillin (as trihydrate) 600 mg

• Clavulanic acid (as potassium clavulanate) 42.9 mg

Pharmacological Class:
Broad-spectrum antibiotic (penicillin group, β-lactamase inhibitor combination)

Dosage Form:
Oral suspension — for pediatric use

Indications:

• Upper and lower respiratory tract infections (sinusitis, otitis media, bronchitis, pneumonia)

• Urinary tract infections

• Skin and soft tissue infections

• Bone and joint infections

• Dental infections

Mechanism of Action:
Amoxicillin inhibits bacterial cell wall synthesis, while clavulanic acid prevents bacterial resistance by inhibiting β-lactamase enzymes. This combination extends antibacterial coverage to β-lactamase–producing organisms.

Dosage and Administration:

• Children (based on Amoxicillin component): Usually 90 mg/kg/day divided every 12 hours.

• Shake the bottle well before each use.

• Administer at the start of a meal to improve absorption and reduce gastrointestinal side effects.

• Reconstitute the powder with boiled and cooled water as directed on the bottle and shake vigorously.

Side Effects:

• Gastrointestinal: diarrhea, nausea, vomiting, abdominal pain

• Skin reactions: rash, urticaria

• Rare: hepatic dysfunction or hypersensitivity reactions

Precautions:

• Contraindicated in patients allergic to penicillins or β-lactam antibiotics.

• Adjust dose in renal impairment.

• Discontinue immediately if signs of allergic reaction occur.

Storage:

• Store reconstituted suspension in a refrigerator (2–8°C).

• Discard any unused portion after 7 days.

• Keep tightly closed and out of reach of children.