Dalacin C 600mg Ampoules

Medication Name: Dalacin C 600mg Ampoules

Active Ingredient:
Clindamycin phosphate (equivalent to 600 mg clindamycin base)

Pharmacological Class:
Lincosamide antibiotic

Dosage Form:
Sterile injectable solution for intramuscular (IM) or intravenous (IV) administration

Indications:

• Severe infections caused by susceptible anaerobic bacteria and gram-positive organisms

• Respiratory tract infections (e.g., pneumonia, lung abscess)

• Skin and soft tissue infections

• Bone and joint infections (including osteomyelitis)

• Intra-abdominal and pelvic infections

• Septicemia and endocarditis caused by sensitive strains

Mechanism of Action:
Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide chain elongation and bacterial growth.

Dosage and Administration:

• Intramuscular (IM): 300–600 mg every 8–12 hours for moderate infections; up to 1200 mg/day for severe infections.

• Intravenous (IV): 600–2700 mg/day in 2–4 divided doses depending on severity.

• Administer IV slowly over at least 10–60 minutes (not as a rapid bolus).

• Dosage should be adjusted based on infection type, patient weight, and renal/hepatic function.

Side Effects:

• Pain or irritation at injection site

• Diarrhea or pseudomembranous colitis

• Nausea, vomiting

• Rash or allergic reactions

• Transient liver enzyme elevation

Precautions:

• Avoid intrathecal administration.

• Monitor liver and kidney function during prolonged use.

• Stop treatment if severe diarrhea develops (risk of Clostridium difficile–associated colitis).

• Use with caution in patients with hepatic impairment.

• Not recommended for newborns under 1 month unless specifically indicated.

Storage:
Store below 25°C.
Protect from light.
Do not freeze.
Keep out of reach of children.