Erastapex Plus 40\12.5mg 30 Tablets

Erastapex Plus 40/12.5 mg (30 Tablets)

Active Ingredients:

• Losartan 40 mg (Angiotensin II receptor blocker, ARB)

• Hydrochlorothiazide 12.5 mg (Thiazide diuretic)

Therapeutic Class:
Combination antihypertensive – ARB + Thiazide diuretic

Indications:

• Hypertension (high blood pressure) in adults, especially when monotherapy is insufficient.

• May help reduce cardiovascular risk and protect renal function in selected patients.

Dosage:

• Usual adult dose: One tablet once daily, preferably in the morning.

• Can be taken with or without food.

• Dose adjustments may be required based on blood pressure response, kidney function, and electrolyte levels.

Mechanism of Action:

• Losartan: Blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone secretion.

• Hydrochlorothiazide: Increases sodium and water excretion, reducing blood volume and lowering blood pressure.

• The combination provides synergistic antihypertensive effect through complementary mechanisms.

Precautions:

• Contraindicated in:

  • Pregnancy and breastfeeding

  • Severe renal impairment

  • Hypersensitivity to losartan or hydrochlorothiazide

• Use with caution in:

  • Electrolyte imbalances (especially potassium)

  • Kidney or liver impairment

  • Heart failure or volume depletion

• Monitor blood pressure, kidney function, and electrolytes regularly.

Possible Side Effects:

• Dizziness or lightheadedness

• Fatigue

• Electrolyte disturbances (low sodium, high potassium)

• Hypotension

• Peripheral edema

• Rare: kidney impairment, angioedema, allergic reactions

Storage:

• Store below 25°C in a dry place, protected from light and moisture

• Keep out of reach of children