Mounjaro 12.5mg\0.6ml 1 Kwikpen

Mounjaro 12.5 mg/0.6 ml (1 KwikPen)

Active Ingredient:

• Tirzepatide 12.5 mg per 0.6 ml prefilled pen

Therapeutic Class:
Dual GIP and GLP-1 receptor agonist (antidiabetic and weight management agent)

Indications:

• Type 2 diabetes mellitus in adults to improve blood glucose control:

  • As monotherapy (if metformin is not suitable)

  • Or in combination therapy with other antidiabetic medications such as metformin, SGLT2 inhibitors, or insulin.

• Sometimes used off-label for weight reduction under medical supervision.

Dosage and Administration:

• Administer once weekly via subcutaneous injection in the abdomen, thigh, or upper arm.

• Can be injected any time of day, with or without food.

• Do not inject into the same site each week—rotate sites to avoid irritation.

• If a dose is missed, it may be taken within 4 days (96 hours); otherwise, skip and resume the next scheduled dose.

• The 12.5 mg dose is typically a step-up dose before reaching the maintenance dose of 15 mg, following titration from lower strengths (2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg).

Mechanism of Action:

• Tirzepatide activates GIP and GLP-1 receptors, leading to:

  • Increased insulin secretion and decreased glucagon levels (glucose-dependent)

  • Delayed gastric emptying

  • Appetite suppression and enhanced satiety

  • Improved glycemic control and weight reduction

Precautions:

• Contraindicated in:

  • Personal or family history of medullary thyroid carcinoma (MTC)

  • Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • Severe gastrointestinal disorders

• Caution in patients with:

  • Pancreatitis history

  • Renal impairment (especially if severe vomiting/diarrhea occurs)

• Not indicated for type 1 diabetes or diabetic ketoacidosis.

• Monitor blood glucose closely if combined with insulin or sulfonylureas due to risk of hypoglycemia.

Possible Side Effects:

• Nausea, vomiting, diarrhea, constipation (most frequent, usually transient)

• Loss of appetite, fatigue, indigestion

• Hypoglycemia (especially with other glucose-lowering agents)

• Rare: Pancreatitis, gallbladder issues, injection site reactions

Storage:

• Store in a refrigerator (2–8°C).

• Can be kept at room temperature (below 30°C) for up to 21 days.

• Do not freeze.

• Keep the pen capped and protected from light.